Search Result

Results for "

nerve growth factor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nuclear Hormone Receptor 4A/NR4A (1) Apoptosis (2) Histamine Receptor (3) Interleukin Related (1) Neurotensin Receptor (1) Reactive Oxygen Species (2) TNF Receptor (1) Trk Receptor (5)
By Research Areas:	Cancer (6) Endocrinology (4) Inflammation/Immunology (9) Neurological Disease (18)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Nuclear Hormone Receptor 4A/NR4A FGFR VEGFR TGF-beta/Smad PDGFR TGF-β Receptor GHSR EGFR IGF-1R

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N11004

Erinacine C

Others Neurological Disease

Erinacine C is a potent stimulator. Erinacine C can be used for nerve-growth factor synthesis .

Erinacine C	Others	Neurological Disease
Erinacine C is a potent stimulator. Erinacine C can be used for nerve-growth factor synthesis .

HY-18314

GW 441756 4 Publications Verification	Trk Receptor Apoptosis	Neurological Disease Cancer
GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC₅₀=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth .

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively .

HY-N12170

Kissoone C	Others	Neurological Disease
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-117517

NG-012	Others	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-124637

ALE-0540	Others	Neurological Disease
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC₅₀ values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain .

HY-108466

Ro 08-2750 2 Publications Verification	Apoptosis	Neurological Disease Cancer
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75 ^NTR selectively over TRKA . Ro 08-2750 is a selective _{MSI RNA-binding} activity inhibitor, with an IC₅₀ of 2.7 μM .

HY-110155A

(Rac)-LM11A-31 dihydrochloride	Others	Neurological Disease
(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75 ^NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist .

HY-110155

LM11A-31 dihydrochloride 5 Publications Verification	Neurotensin Receptor	Neurological Disease
LM11A-31 dihydrochloride, a non-peptide p75 ^NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .

HY-17622

Tavilermide

2 Publications Verification

MIM-D3
Trk Receptor Inflammation/Immunology

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

Tavilermide 2 Publications Verification MIM-D3	Trk Receptor	Inflammation/Immunology
Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

HY-N3482

Isogarciniaxanthone E	Others	Neurological Disease
Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth .

HY-111492

DIM-C-pPhOCH3

Nuclear Hormone Receptor 4A/NR4A Cancer

DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

DIM-C-pPhOCH3	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

HY-N11640

Methyl Ganoderic acid B	Others	Neurological Disease
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N3938

Gelsemiol	Others	Neurological Disease
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N0380

Nardosinone	Others	Neurological Disease
Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .

HY-N3928

Garciniaxanthone E	Others	Neurological Disease
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-146524

TRK-IN-18	Trk Receptor	Cancer
TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .

HY-146523

TRK-IN-17	Trk Receptor	Cancer
TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .

HY-I0021

Bepotastine 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-I0021A

Bepotastine tosylate	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine tosylate is a selective and orally active second-generation histamine H1 receptor antagonist. Bepotastine tosylate can suppress the expression of nerve growth factor (NGF). Bepotastine tosylate can be used in studies of allergic rhinitis, allergic conjunctivitis and urticaria/pruritus .

HY-N12172

Kissoone A

Others Others

Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

Kissoone A	Others	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-A0015

Bepotastine besilate 1 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-P99297

Bedinvetmab ZTS-00508841	Trk Receptor	Inflammation/Immunology
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .

HY-110166

PD 90780 1 Publications Verification	Others	Neurological Disease
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 ^NTR. PD 90780 inhibits NGF-p75 ^NTR interaction with IC₅₀s of 23.1 and 1.8 µM in PC12 cells and PC12 ^nnr5 cells, respectively .

HY-A0015A

(Rac)-Bepotastine besilate	Others	Inflammation/Immunology Endocrinology
(Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce *brain-derived neurotrophic factor* (BDNF)** mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce *brain-derived neurotrophic factor* (BDNF)** mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

Fulranumab	Inhibitory Antibodies	Neurological Disease
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .

Fasinumab	Inhibitory Antibodies	Inflammation/Immunology
Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies .

Frunevetmab NV-02	Inhibitory Antibodies	Inflammation/Immunology
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a K_d of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats .

Bedinvetmab ZTS-00508841	Trk Receptor	Inflammation/Immunology
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs .

Erinacine C	Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Diterpenoids Endogenous metabolite	Others
Erinacine C is a potent stimulator. Erinacine C can be used for nerve-growth factor synthesis .

Negletein 5,6-Dihydroxy-7-methoxyflavone	Structural Classification Flavonoids Scutellaria baicalensis Georgi Flavones Labiatae Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively .

Kissoone C	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

NG-012	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Others
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

Isogarciniaxanthone E	Structural Classification Xanthones Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Phenols Plants	Others
Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth .

Methyl Ganoderic acid B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects .

Erinacin B	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

Gelsemiol	Structural Classification Iridoids Terpenoids Source classification Populus tomentosa Plants Salicaceae	Others
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

Nardosinone	Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae Disease Research Fields	Others
Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .

Garciniaxanthone E	Structural Classification Flavonoids Garcinia xanthochymus Hook. f. ex T. Anders. Flavonones Source classification Guttiferae Plants	Others
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

Kissoone A	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

Species:	Human (11) Mouse (7) Rat (2) Rabbit (1) Canine (2)
Tag:	His (11) Tag Free (8) Avi (2) Fc (4) Flag (1)
Source:	HEK293 (11) CHO (2) Sf9 insect cells (1) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P70456

	Neurotrophin-3 Protein, Human Neurotrophin-3; NT-3; HDNF; nerve growth factor 2; NGF-2; Neurotrophic factor; NTF3	Human	E. coli
	Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions.

HY-P70310

	EGR1/ZNF225 Protein, Human (His) rHuEarly growth response protein 1/EGR1, His; EGR-1; Early growth response protein 1; Zif268; zinc finger protein 225; NGFI-A ; nerve growth factor-induced protein A;	Human	E. coli
	The EGR1/ZNF225 protein is a multifunctional transcriptional regulator that binds to the EGR site in the promoter of target genes and is independent of cytosine methylation. It controls the transcription of multiple target genes, affecting responses to growth factors, DNA damage, and ischemia. EGR1/ZNF225 Protein, Human (His) is the recombinant human-derived EGR1/ZNF225 protein, expressed by E. coli , with N-6*His labeled tag. The total length of EGR1/ZNF225 Protein, Human (His) is 152 a.a., with molecular weight of ~20.0 kDa.

HY-P78091

	CD40 Protein, Human (Biotinylated, HEK293, His-Avi) CD40; CD40L receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CDw40; MGC9013; nerve growth factor receptor-relat	Human	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through TRAF6 and MAP3K8-mediated pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists as monomers and homodimers and interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6). CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD40 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is 173 a.a., with molecular weight of 35-40 kDa.

HY-P700018AF

	Animal-Free Beta-NGF Protein, Human (His) β-nerve growth factor; NGF-β	Human	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.

HY-P73316

	Beta-NGF Protein, Human (CHO) 2 Publications Verification Beta-NGF; Beta-nerve growth factor; NGF; NGFB	Human	CHO
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (CHO) is produced by CHO cells (S122-R239), with tag free.

HY-P73317

	Beta-NGF Protein, Mouse (CHO) Beta-NGF; Beta-nerve growth factor; NGF; NGFB	Mouse	CHO
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (CHO) is produced by CHO cells (S122-G241), with tag free.

HY-P7660

	Beta-NGF Protein, Human (HEK293) rHuBeta-NGF; Beta-nerve growth factor; Beta-NGF;	Human	HEK293
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (HEK293) is produced by HEK293 cells (S122-R239), with tag free.

HY-P7661

	Beta-NGF Protein, Mouse (120a.a) 1 Publications Verification rMuBeta-NGF; Beta-nerve growth factor; Beta-NGF;	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (120a.a) is produced by E.coli (S122-G241), with tag free.

HY-P70449

	Beta-NGF Protein, Human (120a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Human	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Human (120a.a) is produced by E.coli (S122-A241), with tag free.

HY-P70530

	Beta-NGF Protein, Mouse (110a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Beta-NGF Protein, Mouse (110a.a) is produced by E.coli (M130-R239), with tag free.

HY-P72488

	pro-Beta-NGF Protein, Human (223a.a) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Human	E. coli
	Pro-Beta-NGF protein plays a crucial role in the development and maintenance of the nervous system by binding to NTRK1 and NGFR receptors. Immature NGF precursors act as ligands for the SORCS2-NGFR complex, triggering signaling pathways affecting RAC1/2, the actin cytoskeleton, and neuronal growth. pro-Beta-NGF Protein, Human (223a.a) is the recombinant human-derived pro-Beta-NGF protein, expressed by E. coli , with tag free. The total length of pro-Beta-NGF Protein, Human (223a.a) is 223 a.a., with molecular weight of ~30 kDa.

HY-P73456

	TrkA Protein, Canine (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, His) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Canine (HEK293, His) is 126 a.a., with molecular weight of 27-33 kDa.

HY-P73457

	TrkA Protein, Human (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Human	HEK293
	Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.

HY-P73459

	TrkA Protein, Rat (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Rat (HEK293, Fc) is 418 a.a., with molecular weight of 92-102 kDa.

HY-P73460

	TrkA Protein, Rat (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, His) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rat (HEK293, His) is 386 a.a., with molecular weight of ~70-95 kDa.

HY-P73577

	TrkA Protein, Rabbit (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Rabbit	HEK293
	TrkA Protein, Rabbit (HEK293, His) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. TRKA (NTRK1) gene encodes the high affinity receptor for a neurotrophin nerve growth factor (NGF). It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TrkA Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rabbit (HEK293, His) is 382 a.a., with molecular weight of ~43.4 kDa.

HY-P73578

	TrkA Protein, Canine (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of TrkA Protein, Canine (HEK293, Fc) is 126 a.a., with molecular weight of 55-61 kDa.

HY-P76115

	TrkA Protein, Mouse (HEK293, Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Mouse (HEK293, Fc) is 420 a.a., with molecular weight of ~116 kDa.

HY-P76116

	TrkA Protein, Mouse (HEK293, His) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-His, C-8*His labeled tag. The total length of TrkA Protein, Mouse (HEK293, His) is 387 a.a., with molecular weight of ~55-125 kDa.

HY-P700162AF

	Animal-Free Beta-NGF Protein, Mouse (His) beta-NGF; beta-nerve growth factor; NGF; NGFB	Mouse	E. coli
	Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Mouse (His) is produced by E.coli (S122-G241), with C-terminal His-tag.

HY-P73458

	TrkA Protein, Human (HEK293, His-Fc) High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK	Human	HEK293
	TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. TrkA Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkA protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkA Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of 85-95 kDa.

HY-P70530A

	Beta-NGF Protein, Mouse (110a.a, His) Beta-nerve growth factor; Beta-NGF; NGF; NGFB	Mouse	E. coli
	Beta-NGF Protein, vital for developing and maintaining the nervous systems, engages NTRK1 and NGFR receptors, initiating signaling cascades regulating neuronal processes. The NGF precursor, proNGF, acts as a ligand for the SORCS2-NGFR receptor, activating pathways that impact RAC1/2, actin cytoskeleton, and neuronal growth. In vitro, proNGF induces neuronal apoptosis. Beta-NGF inhibits platelet glycoprotein VI proteolysis, binds lysophosphatidylinositol and lysophosphatidylserine, influencing mast cell histamine release. Its homodimer interacts with NTRK1, NGFR, and SORCS2, and proNGF binds to SORT1-NGFR, leading to NGF endocytosis. These interactions highlight Beta-NGF's multifaceted roles in cellular responses. Beta-NGF Protein, Mouse (110a.a, His) is the recombinant mouse-derived Beta-NGF protein, expressed by E. coli, with N-6*His labeled tag. The total length of Beta-NGF Protein, Mouse (110a.a, His) is 110 a.a., with molecular weight of ~12.0 kDa.

HY-P702762

	NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; NTRK-1; NTRK1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; Trka; TRK1-transforming tyrosine kinase protein; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A	Human	Sf9 insect cells

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